From Highway 25 going south from Starkville toward Louisville, look for the green highway sign indicating Noxubee Refuge just after crossing into Winston County. Turn left onto Loakfoma Road at the sign. Follow the road until it ends at a T. Turn left and proceed approximately 9 miles. From Highway 25 going north from Louisville toward Starkville, look for the green highway sign indicating Noxubee Refuge. Pass the first sign. Continue to the next sign - approximately 7 miles - and turn right onto Loakfoma Road. Follow the road until it ends at a T. Turn left and proceed approximately 9 miles. From Highway 45 at Brooksville, look for Noxubee Refuge exit signs. Go through the town of Brooksville and follow the road until it turns to dirt (about 10 miles). Continue straight, go to second 4-way intersection and make a right. Follow sign to refuge. From Starkville (Highway 25/12), look for a sign at the corner with the Hampton Inn (Spring St.). Follow signs south on Oktoc Road to the refuge about 14 miles.